VDR is a gene that encodes a vitamin D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene (rs2228570 FokI polymorphism) is associated with decreased bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and the temporal on-and-off occupancy of VDRE between the two components. It is also affected by chromosomal positioning and binding preferences for specific hormones. Microarray studies of human cells indicate that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for data and documents related to legal transactions, business or proceedings with restrictions on viewing, downloading or printing. It makes use of a central server and an extranet connection that is an Internet connection that has restricted access to allow restricted access to log-in for specific time periods during which users are able to access the documents and data.
Companies and investment banks that are involved in mergers and acquisitions are among the most frequent users of a VDR. They need a secure platform for sharing information with investors or buyers in a manner that is transparent and due diligence may require large amounts of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.